Background: Diabetes complications include nerve damage and poor blood circulation. These problems make the feet vulnerable to skin sores (ulcers) that can worsen quickly and are difficult to treat. The frequency of minor and major amputation increases with the higher grades of diabetic foot. Poor glycemic control is a significant risk factor for amputation in diabetic foot patients. Objective: Objective of this study is to access the various factors and there frequencies which lead to amputations in diabetic foot patients Material and Methods: Study Design: Longitudinal study Study Setting: The study was conducted at Diabetic Clinic, Medical, Surgical and Orthopedic Wards Allama Iqbal Medical College, Jinnah Hospital, Lahore. Duration: One month Inclusion criteria: It includes diagnosed cases of type 1 and type 2 diabetes who had developed foot ulcers and undergone amputations. Data Collection and analysis: The patient agreed to participate will be asked to sign informed consent. A self-designed performa consisting of closed and open ended questions will be provided to each patient. Performa contains demographic related item such as age, gender, ethnicity, address, religion, and economical history of mother and father. A patient will be guided how to fill the performa and be assured that their response will be treated with utmost confidentiality.Data will be entered and analyzed in SPSS Version: 17.0. Results: Total of 70 patients were taken as subjects for the study. Mean age of the subjects was 50.16 years with standard deviation of 6.28 years. 62.86% were males and 37.14% were females. 34.29% were diagnosed of Type 1 and 65.71% as Type 2 DM. 77.14% had DM for 1-15 years and 22.86% had DM for 16-35 years Conclusions: This study has identified that most common and significant predictors were gender, type of DM, duration and onset, PVDs and DFUs. Key words: Diabetes Mellitus, Amputation, LEAs.