Diabetes Mellitus (DM) as ominous presumptive diagnostic of chronic kidney disease (CKD) worsening to end- stage renal damage (ESRD) is one of the spontaneous elicit in general health affair. Diabetes in young age firmly invokes the exceptional cardiovascular risk factors incidence and the progression of diabetic micro and macro angiopathies. Chronic heart failure and myocardial infraction is strongly provoked by latent pathophysiological mechanisms by the potential contributor of hyperglycemia in the hemodynamic derangements with history of diabetes as a vulnerable silent symptom.