A quasi experimental study was done to assess the effect of proximal massage, palm fisting and hot application on reducing the risk of thrombophlebitis among 105 IV cannulated patients admitted in selected hospital of Ambala Haryana. The sample was selected by purposive sampling technique and divided into four groups: PFG (15), PMG (30), HAG (30) and CG (30). The interventions used were palm fisting exercise, proximal massage, and hot application. Data was collected by using VIP scale and VRS scale. Findings revealed that pre test and post test phlebitis mean rank scores at 3rd day were 2.00 (Z=-1.73, p=0.08), 5.00 (Z=-2.89, p=0.00), 6.00 (Z=-3.13, p=0.00) and 8.04 (Z=-3.3, p=0.00) in PFG, HAG, PMG and CG respectively and pain scores were 5.50 (Z=-3.05, p=0.00), 7.00 (Z=-3.29, p=0.00), 4.50 (Z=-2.59, p=0.01) and 8.50 (Z=-3.63, p=0.00) in PFG, PMG, HAG, and CG respectively. There was an association of risk of thrombophlebitis with method of drug administration (ᴎ=1, p=0.04) and with use of anticoagulant drugs (ᴎ=1, p=0.04) in PFG group and pain score with method of drug administration (ᴎ=5.0, p=0.05) in PFG and age (ᴪ=10.48, p=0.01) in CG. The use of hot application was most effective and palm fisting exercise was least effective.