Background: We present a case of a case of sulfonylurea herbicide poisoning of a 65 year containing Sulfometuron methyl (75%). Clinical Presentation: Though the literature suggests they are less toxic to human in acute poisoning, in our case report patient presented with acute respiratory failure, ARDS, metabolic and respiratory acidosis. Conclusion: self-poisoning with these newer non-urea synthetic organic herbicides including metsulfuron-methyl is a newly emerging phenomenon in India. Limited information regarding their toxic effects in human poses several clinical challenges to the treating physician. literature suggests they are less toxic to human in acute poisoning, which is contradictory to the presentation in our case. There is no specific antidote available for sulfometuron methyl poisoning. Thus further documentation and research are needed to contrive more organized understanding in the clinical presentation, fatal possible outcomes of these herbicides? poisoning, thereby formulate a consensus regarding approach in the management.