Alzheimer’s disease (AD) is the most common neurodegenerative disorder that affects millions of people worldwide causing massive economic burden and the number of cases is expected to rise dramatically. Currently, there is no treatment that can stop or reverse the effects of AD. This review attempts to present the current status of research, biopathological approach mechanisms, and nicotine as a therapeutic method in AD. Nicotine has been related to recovery of memory in humans and animal models and some observational studies have been compatible with a protective effect of nicotine inhalation against Alzheimer’s disease. At present, there is great controversy over this possible effect of tobacco use, and evidence is inconclusive.