Jopkiewicz Sylwia. The barrier and the intestinal microflora - the factors determining the state of human health. Journal of Education, Health and Sport. 2019;9(7):408-413. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3347211 http://ojs.ukw.edu.pl/index.php/johs/article/view/7169 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 01.07.2019. Revised: 05.07.2019. Accepted: 23.07.2019. The barrier and the intestinal microflora - the factors determining the state of human health Sylwia Jopkiewicz Orcid: http: /orcid.org/0000-0001-5453-4751 PhD student in the field of health sciences, Jan Kochanowski University, Faculty of Medicine and Health Sciences, ul. IX Wieków Kielce 19, 25-317 Kielce. Address for correspondence: Sylwia Jopkiewicz, Jan Kochanowski University, Faculty of Medicine and Health Sciences, ul. IX Wieków Kielc 19, 25-317 Kielce; tel. 797 186-370, e-mail:Sylwia.Jopkiewicz@wp.pl. Summary Introduction and purpose: Protective function, immune and nutrition in the human body correspond to the intestinal barrier. As a result of excessive exposure to various factors often leads to damage or abnormalities in its functioning, which negatively affects the behavior of human health. The intestinal microflora is important in the process of metabolism, as well as the intestinal barrier plays an important role in establishing immunity and protection. The purpose of this article is to present the importance and the role played by the barrier and microflora in maintaining human health. Description of knowledge:Use of alcohol, non-steroidal anti-inflammatory drugs, antibiotics, completed parasitic infections, viral and bacterial infections, chronic stress and diet deficient in fruits and vegetables cause damage to the intestinal barrier and microflora bacterial dysbiosis. Conclusions:Damaged intestinal barrier is causing loss of control on the elements that penetrate into the bloodstream. Increased permeability of the intestinal barrier contributes to increased risk of developing various diseases. Keywords:intestinal barrier, the intestinal flora, dysbiosis.