Background: Post-menopausal tuberculosis of the female genital tract is a rare condition that has gotten generally little consideration in the literature although it is still frequent in developing nations where cases are not diagnosed nor treated. Case presentation: In this work we report an uncommon case of endometrial tuberculosis in a 63 years old woman. Ultrasonography has revealed a large intra-uterine mass witch was highly suspicious of malignancy. An endometrial biopsy revealed endometrial mucosa with multiple granulomas with caseating necrosis. The patient after the finding was put under antiturberculous chemotherapy for six months. Conclusion: vaginal discharge presented in postmenopausal women must raise attention on the possibility of a genital TB especially in endemic countries.