Introduction The reported morbidity of Oral Squamous Cell Carcinoma (OSCC) and Nasopharyngeal Carcinoma (NPC) throughout the world is high. The dilemma is that numerous patients develop OSCC and NPC who do not have a history of usage or exposure to the established risk factors. Objectives To extract socio-demographic, clinic pathological, histopathological and therapeutic data of OSCC / NPC patients from the online database software of King Fahd Medical City and Saudi Cancer Registry databases and to compare all of these variables with the ?Overall Survival? of OSCC and NPC patients Methods The study was retrospective in nature. It comprised of a cohort of patients treated for Oral Squamous Cell Carcinoma (OSCC) / Nasopharyngeal Carcinoma (NPC) at King Fahd Medical City (KFMC). Frequency distribution, chi-square test and Kaplan-Meier survival analysis Results Following parameters had a statistically significant association with the overall survival of the subjects: Gender (p=0.022), age (p=0.001), T4 sized tumor (p=0.007), N status (p=0.037), M status (p=0.001), histological grading (p=0.043), hemoglobin (p=0.011) and cancer being the cause of death (p=0.001) Conclusion This study has identified clinic pathological parameters, which play an important role in determining the survival outcome of oral squamous cell carcinoma and nasopharyngeal carcinoma patients.