A simple, accurate, precise method was developed for the simultaneous estimation of the Sofosbuvir and Velpatasvir in tablet dosage form. Chromatogram was run through Denali 150 x 4.6 mm, 5m. Mobile phase containing Buffer 0.01NKH2PO4 (4.8 pH) : Acetonitrile taken in the ratio 65:35 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.01N KH2PO4 (4.8PH) buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 220.0 nm. Retention time of Sofosbuvir and Velpatasvir were found to 2.30 min and 3.187 min. %RSD of the Sofosbuvir and Velpatasvir were found to be 0.4 and 0.6 respectively. %Recovery was obtained as 99.85% and 99.76% for Sofosbuvir and Velpatasvir respectively. LOD, LOQ values obtained from regression equations of Sofosbuvir and Velpatasvir were 0.33, 0.99 and 0.43, 1.29 respectively. Regression equation of Sofosbuvir is y = 4401x+18039, y = 3121x+2113 of Velpatasvir. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular quality control test in industries. Key words : Sofosbuvir, Velpatasvir, RP-HPLC.