We performed many simulations in many conditions, calculated many quantities and reported them in the main paper. However, the journal manuscript did not place for so many figures. Nevertheless, the reported values of all simulations rely on the results that were also summarized in the figures. These figures were produced by the Jupyter notebooks analyzing the simulation results. Each figure file has the following nomenclature: TypeOfFigure_concentration_diffusionCoefficient_1or2pop_simulationDuration(long)_Type of PSF. For example: molecule_positions_pure_and_impure_bursts_varying_F_C62_D22_5_psfNumeric - report on the molecular position histograms of pure and impure bursts for varying F values, in the simulation with C=62pM, D=22.5 um^2/s, a NUmerical PSF model and 60s duration of simulation (if nothing appears, it was 60s; if the word long appears, it was 180s).