Objective: The aim of this analysis was to know the ibuprofen effect on bleeding during periodontal surgery. Study design: A Prospective Study. Location and duration: The study was conducted in Nishtar Institute of Dentistry, Multan for one year duration from May 2018 to April 2019. Methodology: In this prospective study we selected total 15 subjects with 8 subjects were females and 7 were males aged between 18 and 55 years, presented to the periodontal clinic. On both posterior maxillary teeth sides Root planning was done. Each subject served as a test and control group. Root planning was done on the upper teeth on right side for the control group and in test group left sided root canal was done. Results: In the experimental group, 400 mg ibuprofen in 3 doses were administered before the operation in 1, 5, 10 hours. Total blood loss and Bleeding time were noted in both groups. There was a statistically obvious difference between total blood volume loss and bleeding time between test and control group. Conclusion: The results of this analysis showed that blood loss and bleeding time increased in periodontal procedure when administered ibuprofen. Key words: Periodontal surgery, blood loss, ibuprofen, bleeding time.