In the present study an attempt was made to prepare and evaluate nanoparticles containing pitavastatin by sonication method. The prepared formulations were characterized by scanning electron microscopy, Fourier transforms infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, nanoparticle prepared were subjected for Particle size, entrapment efficiency, in-vitro drug release. The prepared Nanoparticles are spherical and smooth in surface. The size of nanoparticles 978.85 nm and drug entrapment efficiency was in the range of 80.26% to 95.39 %. The DSC analysis and X-ray diffraction studies indicated that the drug was uniformly dispersed in an amorphous state in the formulation. The in-vitro drug release studies indicated nanoparticles containing pitvastatin prepared by probe sonication methods shows good release rate but formulation Pt9 shows retard drug release from nanoparticles because combination of PMMA & HPC helps to release drug slowly for 24 hours. Results indicated that prepared formulation were intact up to 8 hours. Drug released mechanism follows the Non-Fickian transport. The stability test of optimized formulations are carried out according to ICH guideline, which shown that the formulations were stable in temperature condition. By the use of biocompatible and cost effective polymers like PMMA and HPC we can formulate Nano particulate drug delivery of Pitavastatin in controlled manner with good entrapment efficiency.