bjective: to retrospectively compare the risk of locoregional recurrence (LRR) in patients with node negative early breast cancer between patients who have been treated with adjuvant hypofractionated radiotherapy (HFRT) regimen to those who have been treated with adjuvant conventional fractionation regimen (CFRT). Patients and methods: Medical records of 144 patients with stage I and II breast cancer with negative lymph nodes were reviewed retrospectively. Median follow up was 46 months (range 41.8-50.8) Results:100 patients received adjuvant GFRT while 44 patients received CFRT. LRR rate was 4.9 %. No statistical significance (P-value 0.62) was found between both CFRT (95% CI 89-103) and HFRT (95% CI 107.4-117.4) regarding mean time to local failure. ER and HER2 receptor status and overall radiotherapy treatment time (OTT) were found to be correlated significantly with mean time to local failure. Conclusion:HFRTis equivalent to alternative conventional technique for patients diagnosed with stage I, II node negative breast cancer regarding Locoregional control, disease free survival and overall survival.