Introduction: Acute myocardial infarction is defined as partial acute necrosis of the myocardium caused by persistent and severe myocardial ischemia. Aims and objectives: The basic aim of the study is to analyse the aspirin in combination with clopidogrel in the treatment of acute myocardial infarction patients undergoing percutaneous coronary intervention. Material and methods: This cross sectional study was conducted in Allied hospital, Faisalabad during June 2018 to January 2019. The data was collected from 100 patients of acute myocardial infarction. The data was collected through non-probability sampling technique. The data was divided into two groups one was control and one was study group. Patients in both groups underwent PCI under the guidance of coronary angiography and received conventional drug therapy associated with PCI. Continuous nursing intervention was carried out after operation. Results: The data was collected from 100 patients. The total effective rate of the observation group and the control group was 89.4% and 81.8%, respectively with no significant difference. As regards re-thrombosis the observation group was significantly lower than that in the control group. Before treatment, there was no significant difference in LVEDD and LVESD between the two groups (P>0.05). After treatment, the decrease of LVEDD and LVESD in the observation group was more significant than that in the control group, and the difference was statistically significant. Conclusion: It is concluded that the treatment based on aspirin combined with clopidogrel has better clinical efficacy than aspirin alone. The therapy can effectively improve the cardiac function of patients.