Refractory status epilepticus and super-refractory status epilepticus are the most complex neurological manifestations requiring intensive treatment, because they are associated with high mortality. Diagnosis must be established immeditely, simultaneously with the initiation of treatment. Also, a new term has recently been introduced : New-onset refractory status epilepticus - that defines refractory status epilepticus that it is installed in previously healthy patients without a clear cause of the initial examination. We present the case of a 48-year-old female patient without any medical history or chronic medication that came in the emergency unit with super-refractory status epilepticus of unknown ethiology with late onset and who had fatal outcome