Introduction: Due to advances in medical technology, there is an increase in life expectancy in many parts of the world. They also reflect in better oral health in a number of patients since they still retain their natural teeth into the old age. Aims and objectives: The main objective of the study is to analyze the systemic diseases in patients seen at oral medicine department. Material and methods: This cross-sectional study was conducted in Demontmorency College of Dentistry, Lahore during November 2018 to March 2019. The data comprises of 100 randomly selected patients who visited the OPD of the hospital. A standardized medical questionnaire which included information on age, gender, marital status, education level and occupation, medications, smoking, and alcohol habits were questioned. Results: The data was collected from 100 patients. In our evaluation, diabetes mellitus was the most common systemic disease affecting the population with a rate of 38.3%. In the public system, 35.2% of patients had some type of systemic disease compared to 28.1% of patients in the private clinic; this difference, which was statistically significant (p= 0.003), was due mainly to respiratory disease (3.7% in the public health system versus 1.6% in private practice, p= 0.008) and endocrine-metabolic disease (13.7% in the public system versus 6.3% in private practice, p= 0.001). Conclusion: It is concluded that there is a significant prevalence of patients with medical disorders and who are receiving polypharmacy among individuals requesting dental treatment; this particularly affects the public health service.