Background: The outcomes of treatment and treatment cost are very much helpful to ascertain the disease and treatment effects. Objective: This research aims to assess the QoL (Quality of Life) and treatment cost on the patients of PD (Parkinson’s Disease). Furthermore, it also aims to analyze the correlation of disease treatment, cost and quality of life. Methods: This cross-sectional research was conducted at Jinnah Hospital, Lahore from March 2017 to April 2018 with the help of a survey that included a questionnaire to take the response of the participants. We documented PD associated resource consumption, clinical features and loss of productivity in the past twelve months timeframe. Statistical scales were also utilized in this research for the calculation of cost and communal perspective. Results: Among a total of 110 patients there were 38 females (34.5% female) and 70 males (63.5%); moreover, the information about gender for two patients was missing. Mean age and disease duration were respectively (63.3 ± 11.3) years and (8.2 ± 5.8) years. PDQ-39 summary and EQ-5D score were respectively (48.1 ± 13.4) and (0.59 ± 0.28) which was lower than the age bracket from 45 years to 74 years. There was a significant association between EQ-5D & PDQ-39 (P-Values 20.47 & 0.000). In terms of cost the direct medical cost, direct non-medical cost and indirect cost was respectively 35.7%, 29.4% and 34.9%. There was an increase in the disease duration of one year and a decrease in the utility of EQ-5D of 0.1 which increased the yearly cost from 8% to 10% and 7.8% respectively. PDQ-39 score non-significantly effects the total cost. Conclusions: General public health and severity of the Parkinson Disease highly affect the magnitude of quality of life loss. PD associated cost is enormous which are affected by EQ-5D, disease duration and cost. Keywords: Disease, Parkinson’s Disease (PD), Quality of Life (QoL), Medical, Cost and Disease Duration.