Objective: The purpose of this research work is to assess the painful and swollen appendix because of EV (Enterovirus Vermicularis). Study Design: The removal of appendix from every patient carried out and histopathological assessment of the samples conducted. Study Setting: The collection of the samples carried out from the patients who got admission in Allied Hospital Faisalabad. Study Subjects: The examination of twelve hundred and fifty-three appendices carried out to put light on the available association between the prevalence of enterobius vermicularis & the foundation of the inflammation. The evaluation of the painful and swollen appendix carried out because of enterobius vermicularis. Results: The findings of this case work showed that only nine patients out of twelve hundred and fifty-three patients (0.70%) were available with the infections of enterobius vermicularis, containing five female patients and four male patients from eight to thirty-six year of age. In the time of surgery of two patients from female gender, revealing of cysts of ovaries carried out at the same time. Conclusion: The availability and presence of the enterobius vermicularis in the painful and swollen appendix can be reason of different sign and symptoms and appendicitis inflammation. Keywords: Appendicitis, Vermicular, Enterobius, Foundation, Gender, Infections, Embrocated Egg, Swollen, Large Intestines.