Study was conducted on 108 children who were suffering from uncomplicated enteric fever. The drug efficacy of azithromycin and ceftriaxone was compared. These drugs were advised in following doses, azithromycin at the dose of 10mg/kg/day with maximum dose of 500mg/day and ceftriaxone was given at the dose of 75mg/kg/day and maximum dose of 2.5g/day. 64 patients from the collected sample were detected pre-treatment culture positive for Salmonella typhi.out of 64, 31 were prescribed azithromycin while 29 were prescribed ceftriaxone. The response to both these drugs was significant. No life threatening or clinically significant side effect was observed in any case. Patients who were prescribed ceftriaxone, four of them presented again with relapse. Azithromycin had effective response against salmonella typhi and it can be used for the cue of enteric fever in developing countries. Keywords: Salmonella typhi, enteric fever, azithromycin, ceftriaxone, response, relapse.