This study investigated workplace stress and coping strategies adopted by senior civil servants in Kogi State, Nigeria. It also examined the level of stress and the relationship between stressors and stress. The study is considered significant because it would serve as a guide to the state government to develop appropriate stress-reducing programmes for the senior civil servants. Descriptive research design was adopted for the study. A total of 500 respondents were sampled using the multistage sampling techniques. Data were collected with the use of a validated questionnaire. Gronbach’s Alpha was used to ascertain the internal consistency of the instrument. Descriptive statistics were used to answer the research questions while the hypotheses formulated were tested using Pearson’s Product Moment Correlation and Multiple Regression analyses. The study revealed a moderate stress level among the respondents. A significant relationship existed between stressors and stress. Also, the study revealed that all the predictor variables are factors that could exert influence on strategies for coping with stress. However, sex of the respondents was the best predictor in stress coping strategies. Based on the findings of the study, workshops and seminars that focus on occupational stress and coping strategies should be organized on regular basis by the Civil Service Commission in Kogi State for the senior civil servants.