The present work deals with the study of comparative Seismic Response of RC Framed Multi-storey Buildings with and without Floating Columns in various configurations and with different storey height. To carry out the work two sets of models are taken which differs in storey height of ground floor. Both the sets contain seven models (total fourteen) with different configuration and numbers of floating columns are considered. Various gravity loads are applied and since building is assumed to be located in seismic zone IV, the seismic loads considered accordingly. Models are developed and analysed with the help of STAAD.Pro V8i by performing equivalent static analysis method. Results are obtained and compared in terms of various parameters such as axial force, shear force, moments, node displacements, average storey displacement and storey drift. The study concludes, inter alia, that the diagonal pattern of floating column is preferable as compare to orthogonal pattern and maximum absolute value of the important design parameters appears at ground and first floors.