Aim: The study was carried out to estimate TSH and Cortisol level in preeclamptic women as compare to normotensive women. Material and Methods: The present study has been conducted on 100 preeclampticprimigravidae in their trimester of pregnancy attending O.P.D of janana hospital, J.L.N Medical college Ajmer. 50 healthy primigravidae of similar age group were included in the study, as the control group. Results:In this study we observed that out of 100 patients of preeclampsia in which 82 patients were of mild preeclampsia and 18 patients were of severe preeclampsia. There was significant decrease in level of cortisol in patients of mild and severe preeclampsia. Decrease in level of cortisol was more in severe preeclamptics as compared to mild preeclamptic patients. There was significant increase in level of TSH in mild preeclampsia whereas more increase in severe preeclampsia. Conclusion:In this present study of 100 patients we concluded that from the results all these parameters play an important role in preeclampsia hence the measurement of TSH and cortisol activity may be used in early diagnosis and management of patients of preeclampsia. This can also be useful in assessing the severity of preeclampsia.