Diabetes mellitus refers to a group of common metabolic disorders that share the phenotype of hyperglycaemia. Madhumeha is known to mankind since long, but with brief description. This can be taken as the equivalent of the menace of current era, Diabetes Mellitus. Ayurveda states that it occurs due to bahudravashleshma which leads to medodusti. This medodusti in turn vitiates mamsa, shareerakleda, shukra, shonita, vasa, majja, lasika, rasa and ojas in the vyadhisamprapti which are the ten distinct dushyas in this disease. Diabetes mellitus is counted among the major diseases which are responsible for morbidity and mortality. At least 171 million people worldwide have diabetes; this figure is likely to be more than double by 2030. Around 3.2 million deaths every year are attributable to complications of diabetes. Ayurveda believes in the tenet of ?SampraptiVighatanamevaChikitsa?, hence understanding of MadhumehaSamprapati in detail paves ways for an appropriate and fruitful treatment plan.