Background: Depression is most frequent mood disorder comorbid with physical illness.Objectives: to determine the relationship between Body Mass Index (BMI) and depression among women with primary infertilityMethods: a cross-sectional study included infertile women attending fertility center. Socio-demographic and clinical variables were compiled including BMI. Self-Reporting Questionnaire (SRQ-20) to identify mental illnesses; DSM-V criteria for depression and Hamilton-17 Scale for severity of depression, were used. Results: 80% of infertile women were depressed. BMI was significantly correlated with age, education, monthly income, duration of marriage, smoking, medication, chronic illness, and religion (P<0.001). Depression was significantly associated with BMI (P<0.001). Conclusion: study found high prevalence of depression among infertile women of statistically significant correlation with BMI.