Background: Motivational interview is a client-centered, directive style of counseling that enhances intrinsic motivation to change in order to help resolving the ambivalence that prevents clients from realizing personal goals. Motivational interviewing empowers the client\'s recovery from substance use Aim:the studyaimed to determine the power of counseling during motivational interview on substance users. Design: This study followed a quasi experimental research design. Setting: it was conducted at \"The Psychiatry, Neurology and Neurosurgery Center\"; addiction department which is affiliated to Tanta University, Tanta city, Algharbya Governorate, Egypt. Subject: The subjects of this study were 60 clientsassigned by simple random sampling into two equal groups, experimental and control group. Tools: Three tools were used (1) The Simple Screening Instrument for Substance Abuse (SSI-SA), (2) The General Self-Efficacy Scale(GSES), and (3) Substance Use Recovery Evaluator (SURE). Results:the main results revealed increase in the recovery rate, after implementation of the motivational interviewing sessions. Statistically significant improvement in self-efficacy degree and substance use recovery rate was also observed. Conclusion:The present study concluded that motivational interview plays an important role in substance use recovery. Recommendations: Apply the motivational interviewing sessions in addiction centers, to provide a better prognosis for substance use recovery.