This MIRRI Best Practice Manual has been developed in response to Article 20 of the Nagoya Protocol and Article 8 of the Regulation. It provides guidance for the mBRCs in implementing their ABS institutional policies with regard to genetic resources and associated traditional knowledge, and working procedures for the acquisition of material, including accession, i.e., formal acceptance of new material in the public collections of the mBRCs, for transfer of material including supply to third parties and the delivery of other services. It also aims to increase transparency on how the mBRCs themselves conduct research on their holdings and lawfully utilize the genetic resources and associated traditional knowledge.