Lepidium sativum plant mucilage has been found to be multifaceted polymer that useful in development of efficient pharmaceutical dosage form. Lepidium sativum Linn (family Brassicaceae) it is edible herb contains mucilage and easily available and overall plant parts (roots, leaves and seeds) used to treat various disease condition. It also contains alkaloid moiety, carbohydrates, proteins, saponins, flavonoids, anthracene glycoside and also contain macronutrient, micronutrient. Crude extract of cress seed mucilage shows various biological activity like chemoprotective, antimicrobial, hypertension, bronchodilator, hypoglycaemic. isolation of seed coat mucilage by using various method to formulate efficient excipient and used in various pharmaceutical formulations. in various reported work on garden cress, and we are focused on chemical constituent, Isolation method, characterization, pharmacological profile and multifaceted application of Lepidium sativum.