Communication signals over power-line channels can be affected greatly by impulsive noise (IN). The effect of this noise is commonly reduced with the application of a nonlinear preprocessor at the receiver such as blanking or clipping that blanks and/or clips the received signal when it exceeds a certain threshold. Erroneous blanking/clipping of the unaffected signals can lead to significant performance degradations. It is found that determining the optimal blanking/clipping threshold is the key for achieving best performance. In contract to these studies, we show in this paper that the performance of the nonlinear preprocessing-based method is not only impacted by the blanking threshold but also by the transmitted signal’s peak-to-average power ratio (PAPR). In light of this and for more efficient IN cancellation we, therefore, propose to implement single-carrier FDMA (SC-FDMA), which inherently has low PAPR properties, combined with a nonlinear preprocessor at the receiver.