Supplementary material: Table S1. A list of primers used in the qRT-PCR reactions. Supplementary material: Table S2. The sequences of the mimics, inhibitors, and siRNAs. Supplementary material: Table S3 The 131 common elements in the "DIANA-microT" "miRDB" and "TargetScan" database. Supplementary material: Table S4 The correlation of PTPN1 and MAP3K11 protein expression with clinicopathologic features. Supplementary material: Table S5 PTPN1 expression level between HCC and normal liver tissues. Supplementary material: Table S6 MAP3K11 expression level between HCC and normal liver tissues. Figure S1. miR-125a-5p suppresses proliferation and induces apoptosis in HCC cells in vitro. Figure S2. PTPN1 and MAP3K11 are direct targets of miR-125a-5p in HCC. Figure S3. PTPN1 and MAP3K11 are up-regulated and negatively correlate with the expression of miR-125a-5p in HCC. Figure S4. miR-125a-5p suppresses cell proliferation and induces apoptosis in HCC by targeting PTPN1 and MAP3K11 via the MAPK signaling pathway.