This is a lecture that will be given on April 23, 2019 at Worcester Polytechnic Institute. It is a teaching lecture that highlights certain aspects of biomolecule diffusion through hydrogel engineered substrates and leads the students through a simulation that generates data with respect to their diffusive capability. Up to date code can be found at: https://github.com/centaurius/Hydrogel-ChemicalDiffusion-Sim