Aim:Two silicone based soft denture lining materials (Mollosil, Molloplast-B), and an acrylic resin based soft denture liner (Viscogel) were selected for comparative evaluation of sorption and solubility in different solutions at different time intervals. Methodology: In this study two silicone based soft denture lining materials (Mollosil, Molloplast-B), and acrylic based soft denture liner (Viscogel) were selected for comparative evaluation of sorption and solubility in different solutions at different time intervals. 50 specimens for each material: Mollosil, Molloplast-B and Viscogel were prepared using brass dies of dimensions - 50mm diameter, 0.5mm thickness. The specimens were stored in different solutions (distilled water, denture cleanser and artificial saliva- acidic, basic, neutral), and tested after 1,4 and 16 weeks for sorption and solubility. Analysis of variance was used to find the significant differences between the materials at all time intervals. Result: The acrylic resin soft lining materials had higher solubility (3.920% Viscogel in acidic saliva) and absorption (3.138% Viscogel in distilled water) than Molloplast-B after 16 weeks of aging. Conclusion: The silicone based soft liner Mollosil, showed the highest percentage of sorption and solubility in artificial saliva than in distilled water, while an acrylic based Viscogel showed the highest percentage solubility in artificial saliva, and lowest percentage of sorption in distilled with the exception of Molloplast-B, which showed the highest percentage of solubility and sorption in distilled water, compared to all these soft lining materials.