The aim of the present study was to investigate the antibacterial activity of chloroform, ethyl acetate, hexane and methanol extracts of Ipomoea pes-caprae(Linn.) R. Br. extracts of roots and stem of plant Ipomoea pes-caprae(Linn.) R. Br. The extracts were tested against different clinical bacterial isolates and the antibacterial activity was performed by using well-plate method. The results demonstrated that the methanol extract of Ipomoea pes-caprae stem and ethyl acetate extract of Ipomoea pes-caprae root exhibit strong antibacterial activity. Our results showed that this plant have observable therapeutic effects on potential infectious agents and can be used as an alternate to conventional medicines.