This in-vitro study investigated the effect of immersion and spray atomization technique of disinfection using 0.5% of sodium hypochlorite solution on compression resistance of polyvinyl siloxane and polyether interocclusal recording materials. This study comprised of a total of 60 samples, wherein 30 samples each of polyvinyl siloxane and polyether underwent compression resistance. These 30 samples of each were again divided into 3 subgroups comprising of 10 specimens each - a control group, a group subjected to spray atomization disinfection technique for 10 mins and a group subjected to immersion technique for 10 mins following which they were subjected to compression resistance in a universal testing machine. One-way ANOVA and Post-Hoc Tukeys test were used for statistical analysis. Results showed that Polyvinylsiloxaneinterocclusal recording material showed better resistance to compression than polyether interocclusal recording material and Immersion technique of disinfection was better for polyvinylsiloxane and spray atomization technique of disinfection for polyether. Hence it could be concluded that Polyvinylsiloxane material can be used as an interocclusal recording material because of its greater resistance to compression and can be subjected to immersion technique of disinfection.