Grinding of talc powders has been studied both theoretically and experimentally. The specific rates of breakage of talc powders were measured based on the first-order breakage kinetics model and the cumulative breakage distribution parameters of talc powders were measured from primary breakage products. Based on the measurement results, the specific rate of breakage and cumulative breakage distribution functions were correlated with particle size as and , repectively. A differential-integral equation was thus build to describe grinding as a rate process and was integrated numerically. Comparisons on size distribution showed that the specific rate of breakage of talc powders increased with grinding time at an increase rate about 0.0066min-2.