Objective: We conducted this study to find out the diagnostic results of acute appendicitis via radiological, clinical and laboratory outcomes. Study design: Prospective analytical study. Time and Duration: This study was carried out from November, 2017 to October, 2018 at surgical department of Mayo Hospital, Lahore. Methodology: We included a total number of 150 cases of pain abdomen admitted in the general surgery department with in one to two days. Statistics like preoperative investigations, physical findings and clinical history was investigated from all selected patients and also recorded on a proforma. Carried out systemic, general physical and few specific examinations for acute appendicitis. Also carried out ultrasonography and preliminary hematological diagnosis of pelvis and abdomen. Modified Alvarado scoring system was used to analyze all patients. SPSS V.20 was used for analysis of data. Results: Out of all selected patients (150) we found most cases among the age of 20 years to 30 years which presented a percentage of 34.0% followed by the age group starting form 31 years upto 40 years with a percentage of 26.0%. Found gender of all selected patients as 87 (58.0%) males and 63 (42.0%) females. Tenderness in right iliac fossa and pain in abdomen was observed in all selected patients (100%) and the second most complain observed was the vomiting in 123 (82.0%) patients. Conclusions: According to the findings of our study we concluded that radiological diagnosis is less good than clinical diagnosis. Therefore, it is suggested to use clinical diagnosis for the finding of acute appendicitis than other diagnosis processes as it was observed that positive cases were missed in these processes in a significant number. Keywords: Clinical diagnosis, radiological diagnosis, Acute abdomen, Acute appendicitis, Appendix.