Relations between estimation and information measures have received considerable attention from the information theory community. One of the most notable such relationships is the I-MMSE identity of Guo, Shamai and Verdú that connects the mutual information and the minimum mean square error (MMSE). This paper reviews several applications of the I-MMSE relationship to information theoretic problems arising in connection with multi-user channel coding. The goal of this paper is to review the different techniques used on such problems, as well as to emphasize the added-value obtained from the information-estimation point of view.