On 27 November 2018, cOAlition S has published a guidance document on the implementation of Plan S and has called for feedback from the community on the different topics addressed. The OPERAS Consortium welcomes the Plan S initiative of “making full and immediate Open Access a reality,” which aligns with its own goal. Yet, the solution to how this goal can be reached globally must take into consideration not only the differences between disciplines, but also between countries, languages, and academic communities, especially regarding their communication practices. The OPERAS members are particularly aware that there is not a single path to Open Access. Regarding Open Access policies, bibliodiversity should be adopted as a prime principle, as proposed by the Jussieu Call for Open science and bibliodiversity. The following remarks of the OPERAS Consortium result from the Jussieu principles and the will to positively contribute to the implementation of Plan S.