Pulsatile drug delivery systems are gaining a lot of interest as they deliver the drug at the right place at the right time in the right amount, thus providing a spatial, temporal and smart delivery in increasing patient compliance in designing according to the biological rhythm of the body. Here drug delivery is facilitated according to disease rhythm. The principle rationale for the use of pulsatile release of the drugs is where a constant drug release is not desired. A pulse has to be designed in such a way that a complete and rapid drug release is achieved after the lag time. Various systems like capsular systems, osmotic systems, single and multiple-unit systems based on the use of soluble or erodible polymer coating membranes have been dealt with in the article. It summarizes the latest developments in formulating parameters in release profiles of systems. These systems are beneficial for the drugs having Chrono pharmacological behavior such as a drug used in the treatment of bronchial asthma, myocardial infarction and ankylosing spondylitis like inflammatory disorders. Current review article discussed the reasons for the development of pulsatile drug delivery system in designing of circadian rhythm, types of the disease in which pulsatile release is required, classification, advantages, limitation, and future aspects of pulsatile drug delivery system.