Pediatric asthma is one of the most common chronic airways inflammatory diseases in childhood. The prevalence is increased in last decades in several industrial countries. Allergy has strong relationship to asthma which leads to increase in mucus secretion, and airways hyper-reaction caused by innate and adaptive immune response reactions. Asthma symptoms are wheezing, coughing, breathlessness and using of accessory muscles of the chest. Those are indication of the treatment to the patient can do everyday activities without complications. The treatment depends on the severity of asthma; it should be managed by inhaled corticosteroid combined with long-acting β-2 agonist, leukotriene agonist, theophylline or Cromolyn. Asthma exacerbation is emergency acute attack when symptom intensity is increased and need immediate response to decrease the attack severity. This thesis focuses on management of the childhood asthma in short and long acting therapies. Also, it shows the common side-effect of asthma therapies, and asthma exacerbation, and therapies for life-threating asthma. Finally, a comparison is made between some drugs used for asthma. As references for this thesis, different scientific articles are used from PubMed and Medline. Keywords: asthma, pediatric, asthma exacerbation, inhaled corticosteroids, side-effect, omalizumab.