Background: Due to the lack of data and studies concerning about measurement of population awareness about carpal tunnel syndrome in almjmaah city, this study aims at determining the level of population awareness among almjmaah adult population in Saudi Arabia and measure the prevalence of CTS in almjmaah city. Aims: To study the awareness of carpal tunnel syndrome (CTS) among adult population in Almjmaah city, Saudi Arabia, and to estimate the overall prevalence of CTS. In addition, to look for the relationship between CTS and chronic disease. Also, to determine its effect on social life. Results: The present study has a huge sample size survey gained a rich information through a structured questionnaire by researchers, follow-up duration of mean of year (2018). 54 of participants (14.0%) have carpal Tunnel Syndrome. One third of them are thought that the main symptom is Pain in wrist. on the other hand, one quarter think that Tingling and numbness in fingers is the main manifestation. The most causes that population think that’s it leads to the Carpal tunnel syndrome are Trauma, repeated hand physical activities like using computer and taping, and wrist fracture or dislocation respectively. Also, there is relationship between patients had chronic diseases and carpal Tunnel Syndrome [sig =0.000].Methods: 386 respondents of Almajmaah were participated (42.4% are male and 57.6% female, nearly half are youth aged range between (18-39)). The intervention includes measurement of understanding the clinical features could happen, causes, prevention and management of CTS and the relationship between Carpal tunnel syndrome and chronic diseases. A standardized questionnaire was used to cover 11 different aspects concerning CTS. SPSS package was used to analyze the data collected from the sample. Conclusions: The study shows that the awareness of community was sufficient among adult population and shows that the prevalence of carpal Tunnel Syndrome (CTS) is 14% it is nearly equal the international population prevalence. Also, the study shows there is a strong relationship between CTS and chronic disease. In addition, that population think that the CTS can affect the quality of life Keywords: CTS, clinical feature, prevalence, management, risk factors