Comparison of X-ray crystal structures of a tetradecamer sequence d(CCCGGGTACCCGGG)2 at 1.7 resolution

We presented a comparison of three different X-ray crystal structures of DNA tetradecamer sequence d(CCCGGGTACCCGGG)2 all at about 1.7 Å resolution. The sequence was designed as an attempt to form a DNA four-way junction with A-type helical arms. Crystals did not have any metal ion in the crystallization solution apart from the sodium in the buffer. However, the sequence does not take up the junction structure, but forms an A-type double helix in P41212 space group.

Acknowledgement to Department of Biotechnology, Government of India for data collection facilities at BM14 beamline, ESRF, France.

{"references": ["Gabadinho et al. (2010). J Synchrotron Radiat. 17: 700\u2013707."]}

Related Organizations

University of Madras
India

Keywords

A-DNA duplex; X-ray crystallography; Tetragonal space group; magnesium chloride, A-DNA duplex; X-ray crystallography; Tetragonal space group; zinc interactions, A-DNA duplex; X-ray crystallography; Tetragonal space group; Metal-free state

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