Krzewicka-Romaniuk Ewa, Siedlecka Dagna, Warpas Anna, Wójcicka Grażyna. Paraoxonase 1 as an important antiatherogenic agent. Journal of Education, Health and Sport. 2019;9(1):133-143. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2542320 http://ojs.ukw.edu.pl/index.php/johs/article/view/6476 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eissn 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 03.01.2019. Revised: 11.01.2019. Accepted: 17.01.2019. PARAOXONASE 1 AS AN IMPORTANT ANTIATHEROGENIC AGENT Ewa Krzewicka-Romaniuk1, Dagna Siedlecka1, Anna Warpas1, Grażyna Wójcicka1 1Department of Pathophysiology, Medical University of Lublin ABSTRACT: The inverse relationship between High Density Lipoproteins (HDL) level and risk of ischaemic heart disease was proved by many epidemiological studies. Although the main mechanism of antiatherogenic activity of HDL is a reverse transport of cholesterol from peripheral tissues to the liver, HDL additionally carries some antioxidative enzymes like Paraoxonase 1 (PON1) which protects LDL and HDL lipoproteins from oxidative modification. A lot of antiatherogenic activities of HDL depends on PON1 activity. KEY WORDS: PARAOXONASE, PON1, LIPOPROTEINS, HDL, ANTIATHEROGENIC