The current manuscript presents the iterative user-centred approach that has been followed for the prioritisation and full definition of the Use Cases of a revolutionary C-ITS integrated technological solution newly introduced in the EU funded SAFE STRIP project (GA: n° 723211). This solution aims to shift intelligence from the vehicle to the road infrastructure, in a cost-efficient way, deploying I2X communication technologies and energy harvesting modules to support the micro/ nano sensorial networks that will be embedded on the road pavement surface and will transmit real-time information (static and dynamic) about the road condition, the traffic and environmental conditions to the road users. In this way, a series of C-ITS applications can be supported with real-time, reliable, accurate and lane specific information, directly coming from the infrastructure. Next to the description of the overall approach followed, the key aggregated feedback coming from the stakeholders’ point of view is summarised.