Freight transport and logistics play a key role in economic and social development by ensuring the competitiveness, economic growth and employment. Intermodal transport has received an increased attention due to problems of road congestion, environmental concerns and safety. Strategic importance of speed, reliability in the supply chain is forcing for investments in new logistics transportation hubs. Therefore, the decision assessment framework is an essential challenge linked with the key decision factors meet the stakeholder and decision makers expectations. This paper examines the decision process for developing logistic transportation centers, where a wide range of stakeholders with different expectation is involved. According to a consequences analysis systemic approach, the relationship of logistic transportation hub development, economic system development and stakeholder expectation is analyzed. Adopting a strategic decision making framework with variable defined, the key shareholder’s role and expectations are highlighted. The application provides the methodology outputs presenting the proposed decision framework for a strategic logistics transportation hub in North Greece.