Montelukast sodium is a leukotriene receptor antagonist, used in the treatment of asthma and Desloratadine is a drug used to treat allergies. The combination formulation is used for the treatment of allergic rhinitis, chronic urticaria. The aim of the present study is to Formulate and evaluate the oral disintegrating tablets of Montelukast sodium and Desloratadine. ODTs were prepared by direct compression method and by using crospovidone, croscarmellose sodium and sodium starch glycollate as superdisintegrants which disintegrates in matter of seconds in the oral cavity, thereby reducing the time of onset of pharmacological action and to reduce the first pass metabolism . Magnesium stearate was used as a lubricant, aspartame as sweetener and orange flavour is used to improve mouth feel.