Adverse drug reactions constitute for about 5% of all hospital admissions in India. And it has become one of the leading causes of mortality and morbidity. Due to the use of newer drugs and different prescribing habits the patterns of ADRs may vary in different hospitals. The objective of the study was to identify, assess and analyze the causative drugs associated with various adverse drug reactions and to report clinical patterns of adverse drug reactions in patients to Adverse Drug Reaction Monitoring Centre at SSIMS & RC, Davangere. The prospective observational study was conducted for a period of 6 months. A strict confidentiality was maintained about the patients details. The data was collected from the identified patient’s case sheets. The prescriptions given to the patient was noted on the data collection form. Of the total of 61 reactions reported the most commonly implicated organ system were skin (63.93%). There were 30 males and 31 females. The major causative drug class was antimicrobials (42.62%). More than half of the reactions were classified as probable (67.21%) according to Naranjo’s scale. In this study a total of 30 (49.18%) patients were recovered and 22 (36.07%) patients were recovering during the time of last assessment. In majority of the ADRs reported, the offending drugs were withdrawn (68.85%) and symptomatic treatment was given (70.49%). In our study most of the ADRs were definitely preventable (59.02%). Our study was conducted to improve public health and patient safety by increasing the risk awareness among health care professionals.