The primary objective of the study was the identification, evaluation and analysis of Drug Related Problems (DRPs). This study identifies Adverse Drug Reactions (ADRs) and categorizes drug-drug interactions based on their severity. A prospective observational study was conducted in a tertiary care teaching hospital for a period of 6 months. All inpatients in Medicine, Pediatric, Intensive Care Unit (ICU) and emergency wards with clinical diagnosis of seizure irrespective of age, sex and presence of concurrent diseases were included in the study. Out of 100 patients enrolled, most commonly found etiology was fever, followed by epilepsy. Generalised Tonic Clonic Seizure (GTCS) was found to be the major seizure type. Out of 184 drugs, Hydantoin was the most prescribed class of drug, i.e. 31.52%. The most common drug prescribed was Phenytoin 29.35%. Out of total 190 drug-drug interactions, 9 (4.74%) were major, 111 (58.42%) were moderate and 70 (36.84%) were minor. 59 (59%) prescriptions follows the standard guideline. A total of 17 ADRs were identified. The present study has attempted to reveal the drug related problems in seizure disorder. Even though, majority prescriptions follows standard guideline; a large margin does not. Out of the 17 ADRs found, 11 were due to Phenytoin and 6 were due to Sodium Valproate. Hence, this study has vital role in the treatment of seizure.