Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae) is arid region plant of Amaranthaceae family. It is commonly known as Bui. It is used in folk medicine for the treatment of various ailments such as pain and inflammatory hyperalgesic disorders, rheumatic pain, fever, treatment of wounds and urinary disorders. Aerva pseudotomentosa is a valuable ethnovetrinary medicine to treat health ailments of live stock. Aim of current review to search literature for ethnomedicinal use, pharmacological property, safety/toxicity study, pharmacognostic and physicochemical standardization, preliminary phytochemical investigation of Aerva pseudotomentosa. This compiled data will enable the researchers to identify and differentiate the plant Aerva pseudotomentosa from other similar aerva species and to explore the medicinal properties of different parts of this desert vegetation which are yet to be discovered.