Furan based substituted compounds showed very promising biomaterials such as antimicrobial, anti cancer, antihyperglucemic and analgesic. The poly substituted compounds are employed as building blocks of synthesis of naturally occurring biomaterials which are important in medicinal chemistry. Some of the Benzo furan substituted compounds placed role in asthma, rheumatism and ulcers, Immune nanoparticle of furan based polymeric nanoparticle of biodegradable graft co-polymer to provide a reactive functional group for coupling chemistry of antibodies through Diels-Alder chemistry. Here we enlighten the importance of furan compounds in biomedical application through provoke new findings in this area of research.