From the point of patient compliance, dosage regimen of an orally administered drug may be considered to be optional when the therapeutic effects are maintained for the desired duration of the treatment at the lowest frequency of administration.The development of delivery system from which the active substance is released at a passively controlled release rate over an extended period of time. One of the most rational ways to increase the therapeutic efficacy of drugs consists in creating their ready to use forms with controlled release, which allows the desired therapeutic effects by reduced number of drug intakes, thus decrease the level of toxicity and risk of side effects. The modern ready-to-use medicinal forms for per oral administration with controlled drug release include matrix tablets.